Desulfonylative Alkylation of Electron-Deficient Olefins viaPhotoredox Catalysis

摘要

Sulfones are simple yet versatile synthetic building blocks1 and have recently gainconsiderable interest in late-transition metal catalyzed desulfonylative coupling reactions.2In particular,Ni-catalyzed reductive desulfonylative coupling has been achieved by carefuldesign of the sulfone substrate.3 These strategies rely on excess metal reductants (zinc) togenerate the active alkyl radical species from the sulfone substrate.It can be envisionedsuch process can be achieved using visible-light with a photoredox catalyst.Despite somerecent progress,a general method for radical coupling via photoredox catalyzeddesulfonylation remain a challenge.