Photo-triggered DNA transportation to inside of liposome via construction of DNA nanostructure on liposome surface

摘要

Recently, a growing number of studies have suggested that nucleic acid drugs are promising gene manipulators when combined with other treatments. In particular, small interfering RNA and antisense therapy enable the inhibition of the gene expression. However, such nucleic acid drugs rely on successful delivery to the target. Hence, these approaches require a safe and efficient carrier system for in vivo use. The liposome has useful features for carrying nucleic acids. Therefore, techniques that fix nucleic acids on the surface or inside of liposomes could be useful tools for delivery of nucleic acid drugs.