Enhanced peroxidase activity of hexameric tyrosine-coordinated hemoprotein by substitution of an amino acid residue axially ligating to the heme molecule

摘要

Hexameric tyrosine-coordinated heme protein, HTHP, is a thermally stable homohexamer, which contains a tyrosine-coordinated heme cofactor in each subunit. Although the function of HTHP is still unknown, the rigid and highly-symmetric structure could be useful materials for a newly-engineered protein.1