Coordination chemogenetics for allosteric activation of endogenous GPCR-type glutamate receptors

摘要

Glutamate-mediated excitatory neurotransmission is essential for our memory and learning. Glutamate receptors are categorized into 17 of ion-channel-types and 8 of metabotropic (GPCR)-types, and each of which has essential roles in neurotransmission and synaptic plasticity.