Ligand Directed Acyl Imidazole Chemistry for Drug Sensing of AMPA-Type Glutamate Receptor

摘要

Glutamate is the major excitatory neurotransmitter in the mammalian brain, and whose actions are regulated upon binding to ionotropic and metabotropic glutamate receptors. Among the members of three superfamilies of ionotropic glutamate receptors, α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type ionotropic glutamate receptors (AMPARs) accumulate at synapses and mainly mediate the fast excitatory synaptic transmission in the central nervous system.1