Atrial fibrillation (AF) is the most common pathological arrhythmia diagnosed in horses. Due to the adverse effects encountered when treating with quinidine sulphate we wanted to improve the medical treatment of AF. In this study we aimed to evaluatethe effects of the antiarrhythmic compounds dofetilide and ranolazine in the equine heart. Furthermore, we hypothesized that the use of a combination of two antiarrhythmic compounds with distinct mechanisms would allow us to use lower doses of each compound and thereby minimize the risk of adverse effects.
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