Exocrine pancreatic insufficiency (EPI) in dogs is a syndrome of inadequate synthesis and secretion of pancreatic enzymes, which leads to clinical signs of maldigestion. Previous reports show that small intestinal bacterial dysbiosis occurs in dogs with EPI and is reversed with pancreatic enzyme therapy. However, there are no studies evaluating the fecal microbiome of dogs with EPI. The objective of this study was to compare the fecal microbiome of healthy dogs (n=18), untreated (n=7) dogs with EPI,and dogs with EPI treated with enzyme replacement therapy (n=19).
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