COMPARISON OF FECAL MICROBIOMES BETWEEN DOGS WITH MENINGOENCEPHALOMYELITIS OF UNKNOWN ORIGIN AND CONTROLS

摘要

Recent experiments in laboratory rodents have suggested that the constituents of the fecal microbiome influence the activity of the immune system. Specifically, it has been shown that gnotobiotic rats are resistant to development of experimental autoimmune encephalitis (EAE), an immune-mediated disease of the CNS that mimics aspects of multiple sclerosis in humans and meningoencephalomyelitis of unknown origin (MUO) in dogs. Further experiments have shown that restoration of a normal microbiome abrogates this resistance to EAE.