Applications of bioinformatics tools to combat the antibiotic resistance

摘要

Antibiotic drug resistance is a serious concern world wide. Antibiotics impose selective pressure in spread of resistance genes through exchange of genetic material among bacterial isolates. Addition and excessive use of antibacterial compounds has changed in the microbial populations of the soil, water and our own micro biota. Antibiotic resistance makes us helpless. Now it is the need of era to develop new classes of drugs. But the field of Bioinformatics revolutionize and fascinating the world of science and technology. Now a day's homology modeling technique used to generate 3D structures to evaluate or justify our desirable results. Bioinformatics change the face of molecular studies as to determine the protein structure, gene structure or sequence, molecular markers and relate them to other previously known structures. Bio informatics studies have provided fundamental ways of modeling a biological living cell system and docking proteins that enabled scientists to discover effective drug strategies to combat the diversifying problem of antibiotic resistance among the common casuals of infectious diseases. The field of bioinformatics has involved most pressing task such as the analysis and interpretation of various types of data that includes nucleotide and amino acid sequences, protein domains, protein structures and clear the behavior of protein-ligand interaction at molecular level. The criteria of analyzing the biological annotations or data is referred to as homology modeling or computational biology.