Manganese-Induced Effects on Calcium Homeostasis of the Neurons in Hyline Cocks

摘要

Manganese (Mn) is known to be essential for maintaining the proper function and regulation of many biochemical. To investigate the toxicity of Mn on bird brains, 50-day-old cocks were fed either a commercial diet or a Mn-supplemented diet. the following were determined: Mn concentration, Ca~(2+) concentration, the expression of Calmodulin (CaM) and Calcineurin (CaN) gene. Exposure to Mn significantly lowered expression of CaM and CaN gene. However, Mn was accumulated in brain and the Ca~(2+) concentration was increased. These findings suggested that Mn exposure resulted in the damage of cock cerebral tissue by altering calcium homeostasis, which are possible underlying neurotoxicity mechanisms.