Synthesis of Poly(2-methacryloxy ethyltrimethyl ammonium chloride) Brushes by ATRP on Magnetic Nanoparticles

摘要

Recently, magnetic separation has attracted considerable attention for their increasing applications in biotechnology and biomedicine, especially in the separation of proteins due to ongoing need of purified proteins both in terms of diagnostics and therapeutics [1–3] . In order to increase the loading amount of the biomolecules on the magnetic particles and improve the stability of immobilized biomolecules, the preparation of surface functionalized magnetic particles with water soluble, biocompatible and reactive groups is much desired [4-6] .Therefore, it is of great significance to select nano-sized nonporous magnetic particles as raw material to be modified with suitable polymer in order to obtain enough reactive functional groups on the surface. At present, the most widely used polymerization technique for the growth of polymer brushes from surfaces is atom transfer radical polymerization (ATRP) because it can produce polymer (and copolymer) brushes with narrow molecular weight distributions and for which a broad variety of monomers can be used.