New Cancer Therapeutic Strategies Are Proposed Based on Evidence from Stroma Liquid Biopsy? Biomarkers

摘要

There are a variety of approaches that can characteristically describe a "liquid biopsy". These include detecting tumor cells shed from the primary tumor that become blood-borne, and circulating nucleic acids that are remnants from the tumor cells and must be distinguished from the vast amount of nucleic acids from normal tissue in circulation. Extracellular vesicles are also shed from tumor cells and can be analyzed in the general circulation for tumor-specific components. Nevertheless, tumors are more than simply a collection of immortalized cells. Cancers of high-grade malignancy do not arise in a strictly cell-autonomous manner, but rather must be viewed as an entire ecosystem which cannot be fully characterized through the autonomous properties of only proliferating cells, without consideration for the supporting microenvironments or stroma. Because of this, tumor characterization cannot be fully characterized solely through the analyses of the tumor cell genome - the current emphasis of liquid biopsy platforms.