MSC-laden anti-inflammatory hydrogel improving wound healing of diabetic skin ulcer

摘要

we designed the biocompatible hydrogel which can inhibit the chronic inflammation at the wound sites of diabetes caused ulcer, on this base, we used this hydrogel to package BMSCs for transplantation into these unhealing wound. This treatment resulted in the rapid healing of these unhealing wounds by promoting granulation tissue formation, angiogenesis, extracellular matrix secretion, wound contraction, re-epithelialization, regeneration of hair follicle and sebaceous gland, and reducing scar formation. Furthermore, we demonstrated that the hydrogel enhanced BMSCs' TGF-β1 and bFGF secretion, thereby producing a series of beneficial biological events.