Bridging the Gap: Assessing an Engineered Biomimetic Periosteum on Bone Allografts for the Reconstruction of Large Segmental Bone Defects in Mice

摘要

Our engineered biomimetic periosteum was validated as a vehicle for cell transplantation. Luc-ASCs persistence in the femoral defect site was found to be 7 days, similar to work by Hoffman et al. Inadequate vascular supply is the most likely cause for transplanted cell death. Effect of engineered biomimetic periosteum on allograft incorporation will be evaluated with μCT and histological analysis. This data will inform the design of future preclinical studies for potential clinical translation of an engineered biomimetic periosteum.