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Priming Neural Stem Cell Transplants to Dynamically Respond to Brain Injury Induced SDF-1α Gradients

机译:引发神经干细胞移植动态响应脑损伤诱导的SDF-1α梯度

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Culture on the HA-Lm hydrogel significantly upregulates CXCR4 in NPSCs, which serves to biochemically prime NPSCs for the SDF-1α rich injury microenvironment. Moreover, HA-Lm hydrogel supports NPSC chemotactic migration in response to the injury-relevant chemokine SDF-1α. Mechanistic studies are currently underway to further investigate the regulation of CXCR4 expression and the NPSC chemotactic response. Therefore, this hydrogel delivery system may be a viable option for improving NPSC engraftment in neurotransplantation paradigms.
机译:Ha-LM水凝胶上的培养显着上调了NPSC的CXCR4,其用于SDF-1α丰富的损伤微环境的生物化学素。此外,HA-LM水凝胶响应于相关的趋化因子SDF-1α支持NPSC趋化迁移。目前正在进行机械研究以进一步调查CXCR4表达和NPSC趋化反应的调节。因此,该水凝胶递送系统可以是改善神经递除范例中的NPSC植入的可行选择。

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