Importantly, this work introduces spatial control of biochemical signaling in a scaffold with more biophysically relevant features (hydrogel mechanics, nanofibrous topography), thus enabling tissue-engineering strategies that better mimic natural ECM architecture. Ongoing and future work is underway observing cell response to spatial signaling in scaffolds with nanofiber alignment (attained through electrospinning mandrel collector speed) to further probe the roles biochemical and biophysical signals play in altering cell responses.
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