Surface Grafting of Chitosan-Coated Electrospun Fibers to Promote Cell Adhesion

摘要

The results suggest that co-axial electrospinning can produce meshes comprised of micro-fibers with PCL cores and chitosan sheaths. Further, the chitosan sheath phase appears to be stable in water, and the primary amines in the chitosan are available for subsequent bioconjugation. Bio-conjugation of RGDC to microfibers improves initial cell adhesion and spreading.