ATP-Responsive Hybrid DNA/Graphene Nanoassemblies for Anticancer Drug Delivery

摘要

In summary, we have developed a new ATP-mediated controlled drug release system comprised of a 2D nanomaterial (GO) assembled nanoaggretes crosslinked by ATP-responsive DNA strands. The straightforward formulation design, high loading capacity of drugs and capability of site-specifically promoting drug release render this formulation as a promising strategy for enhanced therapeutic efficacy in cancer treatment.