DEVELOPMENT OF A NOVEL TARGETED MICROPARTICLE DRUG DELIVERY SYSTEM FOR CANCER MEDICATION

摘要

Microparticles were successfully created using a W-O-W process and demonstrated a controlled release of HSA/Paclitaxel over a 28 day period. Biotin was successfully attached to the outer surface of the particles and the functionality of the targeting mechanism was confirmed with their attachment to the SKBR3 cells. The decrease in cell viability by adding the drug and targeting mechanism prove the benefits of the microparticle/targeting complex. Future studies will examine how to decrease the microparticle size and decrease the burst phase of drug being released. In parallel, a different drug/targeting combination will be selected to further validate the functionality of the design.