Cathepsin-K Targeting Nanotherapeutics for Regenerative Repair of Abdominal Aortic Aneurysms

摘要

Our studies indicate the cathepsin-K Ab conjugation is a useful modality to improve targeted binding of our DOX NPs to cytokine-activated aneurysmal SMCs within AAAs, and does not compromise the pro-elastin regenerative and anti-proteolytic effects due to the combination of our unique cationic amphiphile-functionalized nanocarriers and DOX released therefrom.