Cambios en el Acople Neurovascular Inducidos por el Zolpidem en el Estado Vegetativo Persistente: Estudio de RMN funcional

摘要

We studied the hemodynamic and metabolic changes, underlying paradoxical effect of Zolpidem, in a pa-tient in Persistent Vegetative State (PVS), using magnetic resonancc imaging (MRI) based on BOLD signal and proton spectroscopy (~1H-MRS). Significantly increased BOLD signal were transiently localized in frontal cortex. Increased leveis of N-Acetyl-Aspartate, Glutamine-Glutamate and Lactate were localized in the same region. Significant linear correlations between BOLD signal and metabolites concentrations were found. We discussed that Zolpidem attaches receptors of the neurodormant cells, leading a dormancy switched off and inducing brain activation. We concluded that ~1H-MRS and BOLD signal assessment might contribute to study neurovascular coupling in PVS cases after Zolpidem administration.