Anisotropic nature of pharmaceutical powders and its effects on processing and formulation (PPT)

摘要

1. Chemical Heterogeneity 1.1 Surface contaminants and impurities 1.2 Different crystal planes can exhibit different chemistry 1.3 Degree of crystallinity/amorphicity 1.4 Morphological state: polymorphs, hydrates and solvates 1.5 Surface groups/Inhomogeneous surface modification 2. Structural Heterogeneity 2.1 Crystals may have several defect sites 2.2 Growth steps, crystal edges, surface pores, etc. 2.3 Irregularities of crystal lattice 2.4 Pore of different sizes and shapes Heterogeneous properties cause differences in adsorption energies, thus vapor sorption capacity and surface energies