Thermo-Responsive Electrospun Ultrathin Fibers from Poly (OVAG-co-NIPAAm)

摘要

Novel double-hydrophilic thermosensitive glycopolymers,poly (6-O-vinyladipoyI-D-glucose-co-N-isopropylacryamide) (OVAG-co-NIPAAm) were fabricated using a chemoenzymatic and free radical copolymerization process.The molar mass distributions determined by gel permeation chromatography (GPC).In this work,we integrate double-hydrophilic thermosensitive random glycopolymers,enzymatic transesterification and electronspinning to achieve our goals of fabricating smart and targeted copolymer,and presented the first study of electrospinning ultrathin fibers made from the resultant copolymers.Oral fast-dissolving drug delivery membranes (FDMs) for poorly water-soluble drugs were prepared via electrospinning technology with ibuprofen as the model drug and poly(OVAG-co-NIPAAm) as the filament-forming polymer and drug carrier.The ibuprofen-loaded fiber membrane was dissolved very rapidly once the membrane touched water.The average dissolution time for the fiber membrane was about 4 s± 1.5 s.