Integrated Waveguide Mixer-Splitter for Lab-on-a-Chip Applications

摘要

A novel integrated optical component useful for two-species detection, particle velocity measurement and cell-sorting in lab-on-a-chip devices is described. The component consists of dual waveguides that can simultaneously deliver light of two wavelengths to two fixed points in a microchannel. Labeled cells in the channel can be detected by laser-induced fluorescence stimulated by either wavelength or their velocities determined by measuring the time between peaks in the captured signals. The properties of the integrated optical component are determined by simulations and measurements and the measurement of velocities of fluorescent particles in pressure-driven flows is demonstrated.