Issuesand Strategies for Modeling Gene Regulatory Networks

摘要

The objective of system biology is to develop the empirical mathematical model of biological systems formed by the interactions between various complex biological data. Gene regulatory networks are developed to explain the complex nature of gene regulation using genomic data. This paper discusses the construction of gene regulatory network using multi-omics genomic data. The major focus is on exploring various modeling schemes, issues and challenges in the construction of gene regulatory network. In this paper, the outline of different techniques, their strengths and limitations have been discussed.