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Predicting Mortality in Liver Transplant Candidates

机译:预测肝移植候选人的死亡率

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Donated livers are assigned to eligible matches among patients on the transplant list according to a sickest-first policy, which ranks patients by their score via the Model for End-stage Liver Disease (MELD). While the MELD score is indeed predictive of mortality on the transplant list, the score was fit with just three features, for a different task (outcomes from a shunt insertion procedure), and on a potentially un-representative cohort. These facts motivate us to investigate the MELD score, assessing its predictive performance compared to modern ML techniques and the fairness of the allocations vis-a-vis demographics such as gender and race. We demonstrate that assessing the quality of the MELD score is not straightforward: waitlist mortality is only observed for those patients who remain on the list (and don't receive transplants). Interestingly, we find that MELD performs comparably to a linear model fit on the same features and optimized directly to predict same-day mortality. Using a wider set of available covariates, gradient-boosted decision trees achieve .926 AUC (compared to .867 for MELD-Na). However, some of the additional covariates might be problematic, either from a standpoint of procedural fairness, or because they might expose the process to possible gaming due to manipulability by doctors.
机译:根据一个疾病的第一政策,将捐赠的肝脏分配给移植名单上的患者中的符合条件的匹配项,该持续政策将患者通过终末期肝病(MELD)进行分数。虽然MELD评分确实在移植名单上的死亡率预测,但是分数只有三个特征,对于不同的任务(来自分流插入程序的结果),以及潜在的未代表队列。这些事实使我们能够调查融合得分,评估其与现代ML技术相比的预测性能和分配的公平,如性别和种族等人口统计学。我们证明,评估融合评分的质量并不简单:仅针对那些留在清单(并且不接收移植)的患者仅观察到候补性死亡率。有趣的是,我们发现Meld相当于线性模型符合相同的特征,并直接优化以预测相同的死亡率。使用更广泛的可用协变量,梯度提升决策树实现.926 AUC(与MELD-NA相比.867)。然而,一些额外的协变量可能是有问题的,无论是程序公平的立点,还是因为它们可能会使这个过程暴露于由于医生的操纵可能的游戏。

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