Different Amount of Ginseng Encapsulated in Poly (lactic-co-glycolic acid) Microcapsules: A Preliminary Study

摘要

Panax Ginseng has been utilized for its multiple effects such as preventing tumor, treating diabetes and cardiovascular disease and for antioxidant activities. These capabilities captured our interest to evaluate the encapsulation of different amount of ginseng (30 mg and 60 mg) within poly(lactic-co-glycolic acid) (PLGA) microcapsules by a double emulsion technique. The microcapsules were characterize by using attenuated total reflectance-Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The results suggest that all microcapsules were successfully fabricated and the ginseng was successfully encapsulated in the PLGA microcapsules when the chemical functionality of ginseng (O-H and C=C bands) was found on both PLGA microcapsules contained 30 mg and 60 mg of ginseng. The morphology of microcapsules was in a spherical shape with smooth wall surfaces. The PLGA microcapsules with 30 mg ginseng has smaller size of microcapsules compared to the PLGA alone and more homogenous than the PLGA and PLGA microcapsules with 60 mg ginseng. The PLGA microcapsules with 60 mg ginseng were also found agglomerated in some area. As a conclusion, the amount of 30 mg ginseng within the PLGA microcapsules is seen practicable for the development ginseng encapsulated microcapsules for the application of drug delivery and coating materials.