Disposable and versatile optical sensors for SERS analysis of liquid samples by fiber-based spectroscopy

摘要

Optical detection techniques based on surface enhanced Raman spectroscopy (SERS) can provide relevant informationon molecular and protein composition of biological samples, thus enabling to discriminate between physiological andpathological conditions. With the attempt to develop point-of-impact diagnostics devices, in this study we combine lowcostfabrication processes with surface functionalization strategies for the fabrication of SERS-active polymericsubstrates engineered to selectively detect specific biomarkers. By reversibly coupling these devices with the distal endof portable Raman instruments, SERS measurements could be potentially implemented for the early diagnosis ofwidespread pathologies by SERS analysis of liquid biopsies.