Fe3O4/eggshells composite as green catalyst for Hantzsch condensation in acridine synthesis

摘要

Acridine derivatives are a class of nitrogen heterocycles which have broad spectrum of important biological properties and pharmaceutical applications.Low-cost eggshells waste material was used as source of CaCO3 to modified magnetic Fe3O4 particles prepared from co-precipitation to serve as reusable heterogeneous catalyst.The synthesized eggshells based catalyst is characterized by X-ray diffraction(XRD)and TEM studies.The activity of the catalyst has been investigated in Hantzsch condensation reaction with good yields and simple work-up procedure.The synthesis of acridine derivative was achieved through a one-pot,three-component condensation of dimedone,aryl amine and aryl aldehydes utilizing Fe3O4/eggshells composite as catalyst under mild conditions.Maximum yield obtained is 91.3% with reflux condition,amount of catalyst 0.0254 g,and 1.5 h reaction time.Catalyst used can be separated magnetically and can be reused up to three times without significant decrease of yield.The synthesized compound was characterized using IR,UV-Vis and LC-MS.