This study, investigates the relationship between retinal image features and β-amyloid (Aβ) burden in the brain with theaim of developing a non-invasive early detection method for Alzheimer’s disease (AD). 172 retinal images from 20clinically probable AD and 45 age-matched control cases were acquired using a hyper spectral imaging system. BrainAβ accumulation was estimated from amyloid PET imaging. Spatial and spectral features from the hyperspectral retinalimages were calculated including vessels tortuosity and image textures at different anatomical regions. Retinal veins ofamyloid positive subjects (Aβ+) showed a higher mean tortuosity compared to the amyloid negative subjects (p<2.4e-7).Furthermore, a significant difference between texture measures of retinal arteries and their adjacent regions wereobserved in Aβ+ subjects when compared to the Aβ- (p<1.3e-5).
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