Intestinal Small Cell Lymphoma: Are Dogs Big Cats?

摘要

Previously T-cell lymphomas of the gastrointestinal tract in humans were classified as enteropathy-associated T-cell lymphoma (EATL) type I and type II. Type I is associated with celiac disease and characterized by large lymphocytes, whereas type II is not associated to enteropathies and characterized by small lymphocytes. In view of these differences, the nomenclature has been changed and EATL currently refers only to type I and type II has been renamed monomorphic epitheliotropic intestinal T-celllymphoma (MEITL).1 EATL has an aggressive clinical course and tumor cells most commonly have an a(3 T-cell receptor phenotype. In comparison MEITL tumor cells express CD8, CD56, and megakaryocyte-associated tyrosine kinase.