Microbial Delivery of Antimicrobial Peptides for Protection Against Multidrug-Resistant Pathogens

摘要

Antibiotics are vital for all modern medicine but the recent era when bacteria killed only in exceptional cases may be coming to an end.There are over 2,000,000 infections resulting in 23,000 deaths from antibiotic-resistant bacteria(ARB)estimated in the US every year,and the trends of increasingly frequent multidrug-resistant pathogens are disconcerting.A strong argument can be made that unless we invest in new antimicrobial technologies,the threat of multi-or,worse,of pan-resistant bacteria may become massive,global and lethal.Currently,intensive care unit patients,surgery patients,burn patients and cancer patients are at particular ARB infection risk.Whether treated surgically or with radiation or chemotherapy,these patients are more susceptible to infections than healthy individuals.Consequently these patients are routinely treated with antibiotics.