Effect of Water Decoction of Langsat Bark (Lansium domesticum Corr.) on Estrous Cycle and Uterus Weight in Mice (Mus musculus L.)

摘要

The study aims to determine the effect of water decoction of Langsat's bark stew on estrous cycle and uterus weight in mice. Twenty adults, healthy, female mice were divided into four groups, each given 1 mL of Langsat's bark stew with water concentrations of 20%, 40%, and 60%, as well as a control group that was given water ad libitum for twelve days. Estrous phases were determined every day; on the thirteenth day, all mice were euthanized and the uteruses were weighed. The observation of estrous cycles showed that there was no significant difference in the frequency of the phases of the estrous cycle between the control group and the treatment group. Uterine weight treatment groups were higher than in the control group in line with increasing doses, but this was not statistically significantly different.We conclude that water decoction of Langsat's bark stew does not affect the estrous cycle and weight of the mice uterus, and its use as an anti-fertility treatment has not been proven.