Influence of Radiofrequency Electromagnetic Radiation on Magnetic Properties of Magneto-Mechanochemically Synthesized Antitumor Nanocomplex

摘要

62.1 Introduction Iron oxide nanoparticles (NP) have been widely used in therapeutics of experimental tumors because of their unique size, magnetic properties, and ability to interact with a number of biomolecules [1]. We have developed a new cancer magnetic nanotherapeutic technology based on the ability of external electromagnetic field (EMF) to induce the changes in electron transitions in complex composed of semiconductor materials such as ferromagnetic iron oxide Fe_3O_4 NP and antitumor drug [2]. The technology is based on known semiconductor materials' ability, in NP, to generate oxygen radicals and oxidative stress in biological media. Based on advanced studies of electromagnetic radiation (ER) on oxidative stress reactions, the potentially effect of ER on living organisms is that exposure to magnetic field can increase the activity, concentration, and life time of paramagnetic free radicals, which might cause oxidative stress, genetic mutation, and/or apoptosis [3, 4].