Antimicrobial Susceptibility and Biofilm-Producing Ability of Staphylococcus aureus Isolated From Clinical and SubclinicalMastitis in Dairy Cows

摘要

Mastitis is an inflammation of the mammary gland caused mainly by bacteria, which can be manifested as clinical or subclinical. Antimicrobial therapy is one of the main practices for intramammary infection (IMI) treatment. However, treatment success is dependent on the antimicrobial's susceptibility of the causative pathogen. Bacterial biofilm production is a virulence factor that may increase the failure of antimicrobial therapy, which is expressed by microorganisms after exposure to hostile conditions. This virulence factor hinders the action of antibiotics by inhibiting the direct contact of the active ingredient with the mastitis-causing pathogens. Staphylococcus aureus is one of the major contagious pathogens with potential to cause chronic mastitis, and have antimicrobial resistance. Part of this resistance of S. aureus to the antimicrobials used to treat IMI might be associated with its biofilm-producing ability. The objective of this study was to evaluate the association between antimicrobial resistance and the biofilm-forrning ability of 5. aureus isolated from clinical and subclinical mastitis.