FORMATION OF COMPLEX MICELLES WITH DOUBLE-RESPONSIVE CHANNELS FROM SELF-ASSEMBLY OF TWO DIBLOCK COPOLYMERS

摘要

Establishing an effective method to prepare desirable nanostructures and to eventually convert them into designed architectures represents an increasing interest in nanotechnology, chemistry and biology. Proteins that are located in the phospholipid bilayer of cell membranes are important in forming transient pores or channels to achieve ion transport, signal recognition and other biological processes. It is now well-established that amphiphilic block copolymers can self-assemble into lipid-like membranes with tunable channels which considerably expand the properties of natural biomembraneS. However, few studies involved block copolymer micelles with channels. Typical polymeric micelles consist of a compact core formed by the insoluble blocks and a stretched shell formed by the soluble blocks. Many efforts have been made to broaden the range of potential applications and to fabricate novel types of micelles with special and controllable structures. Considering the multifunction of channels, it would offer more advantages if we combine the properties of polymeric micelles with tunable channels.