Solid Lipid Nanoparticles from active compounds of Mango seed kernel extract

摘要

The bioactive compounds in Mango seed kernel have high antioxidant activities which can be used as an ingredient in cosmetic products. The aim of this study was to improve the stability of bioactive compound in seed kernel extract by preparation in the form of solid lipid nanoparticles (SLN). Solid lipid nanoparticles (SLN) were prepared by high-speed homogenization technique. The effect of formulation on introduction the extract into the base solid lipid nanoparticle system was investigated. At the optimal condition, the particle size was 329.1 nm. The highest load efficiency was 89.12%. The physical stability under the different storage temperature for 15 days indicated that the mango kernel extract entrapped in nanoparticles showed good stability. No obvious changes of clarity and degradation were found.