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DIAGNOSIS IMHA: THE COOMBS' TEST

机译:诊断IMAM:COMBS的测试

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摘要

Immune-mediated hemolytic anemia (IMHA) is one of the most common and serious hemolytic anemias in dogs, but occurs rarely in other animal species. In IMHA an immune response, including anti-erythrocytic antibodies, complement and macrophages, targetsdirectly or indirectly erythrocytes and a hemolytic anemia ensues. There are many triggers for IMHA such as infections, drugs, and cancer leading to secondary IMHA, but in many dogs no cause is identified (so-called idiopathic, autoimmune or primary IMHA) or a genetic predisposition has been proposed (Cocker spaniels). Furthermore, alloimmune hemolytic anemias, such as hemolytic transfusion reactions, both acute and delayed, and neonatal isoerythrolysis (only litters from transfused bitches), are caused by specific anti-erythrocytic alloantibodies. In contrast to other species, dogs with IMHA also develop an often overwhelming inflammatory response resulting in thrombosis and necrosis of various organs. And while the anemia can be corrected with transfusions, these complications in dogs are causing severe morbidity and mortality despite aggressive immunosuppression and antithrombotic interventions. This session will review the diagnostic approach to IMHA with special emphasis on the Coombs' test including a comparative prospective study of different Coombs' tests.
机译:免疫介导的溶血性贫血(IMHA)是狗中最常见和最严重的溶血性贫血之一,但很少发生在其他动物物种中。在IMHA中,包括抗红细胞抗体,补蛋白和巨噬细胞,靶向一致或间接红细胞和溶血性贫血的免疫应答。 IMHA有许多触发器,如感染,药物和癌症,导致继发性炎症,但在许多狗中没有鉴定出原因(所谓的特发性,自身免疫或原发性IMAH)或遗传易感性(可卡犬)。此外,同种疫血栓溶解偏瘫,例如溶血输血反应,急性和延迟,新生儿Isoerythroly(仅来自转发母狗的窝点)是由特异性抗红细胞的含量引起的。与其他物种形成鲜明对比,患有IMHA的狗也发展出一种常压倒心的炎症反应,导致各种器官的血栓形成和坏死。虽然贫血可以用输血纠正,但狗的这些并发症尽管存在激进免疫抑制和抗血栓干预措施,但仍会导致严重的发病率和死亡率。本届会议将审查IMHA的诊断方法,特别强调COMBS试验,包括对不同COMBS测试的比较前瞻性研究。

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