A multimodal imaging agent for intrinsic surface enhanced Raman scattering of biological tissue

摘要

Raman imaging is an optical method that provides chemo-selective contrast, microscopic resolution and multiplexing capability. Medical applications, however, still suffer from weak signals and resulting long acquisition times. Plasmon resonance effects can drastically increase signals for Surface Enhanced Raman Scattering (SERS). Here, we present concepts towards an ideal, multimodal SERS agent for medical applications. Enhancement of intrinsic spectra of biological tissue is combined with contrast in Photoacoustic- and Magnetic Resonance Tomography, making this imaging agent highly promising for clinical radiology.