HOLLOW HIERARCHICAL HYDROXYAPATITE/AU/ POLYELECTROLYTE HYBRID MICROPARTICLES WITH SMART DRUG DELIVERY PROPERTY

摘要

Multiple stimuli-responsive hollow micro- and nano-capsules have recently attracted increasing attention, due to their potential applications as novel functional drug carries. In this work, hollow HAP/Au/polyelectrolyte hybrid microparticles with a hollow HAP core and polymer multilayer/Au nanoparticles (AuNPs) shell for multi-responsive drug delivery have been prepared via layer-by- layer (LbL) technique. Thermal-/pH- dual responsive aliphatic poly(urethane-amine) (PUA) was employed as the smart component. Upon irradiation with near-infrared (NIR) laser, AuNPs aggregates can effectively convert light to heat and result in the rapid release of DOX due to the partial collapse of the polyelectrolyte multilayers. In addition, thanks to the dissolution of HAP in the acidic media and the shrinkage of aliphatic PUA above its lower critical solution temperature (LCST), the drug release of hollow hybrid carriers exhibit distinuished pH- and thermal-dependent property. The results indicate that the hollow HAP/Au/PUA/PSS hybrid microparticles show great potential as a novel smart drug carrier for the controllable drug delivery.