Biological and lipid metabolism abnormalities in children and teenagers with HIV/AIDS undergoing antiretroviral treatment.

摘要

In this article we intend to evaluate the lipid metabolism in children and teenagers with HIV/AIDS undergoing antiretroviral treatment. There are almost 1000 children and teenagers on antiretroviral treatment under the direction of the pediatric department of The National Institute of Infectious Diseases "Prof. Dr. Matei Bals".We conducted a retrospective surveillance on a cohort of 130 HIV seropositive children diagnosed in our clinic, none of which had previous lipid metabolism abnormalities. They were put on a treatment with two reverse transcriptase inhibitors (2 NRTI) plus a boosted protease inhibitor or ritonavir (Pl/r). For the patients in the selected cohort we monitored biochemical changes possibly induced by antiretroviral therapy (blood sugar, triglycerides level, cholesterol and total lipids levels).The majority of abnormalities were low or medium grade. We registered only three cases in which the biological changes were significant and required ceasing the treatment.After 12 months of antiretroviral treatment, approximately 3 0 % of the patients treated with two NRTI + PI/r presented lipid metabolism abnormalities; 8.4% of the cases presented high blood sugar levels, 34.6 % of the cases presented hypercholesterolemia, 38.4 % had high triglycerides levels and 36.9% presented high levels of the total lipids.The lipid metabolism abnormalities were far more important in patients treated previously with antiretrovirals, especially the ones who received protease inhibitors, compared with the treatment-naive patients.