Topology analysis of a metabolic functional gene transcriptional regulatory network of Escherichia coli

摘要

Under the perspectives of network science and systems biology, the characterizations of transcriptional regulatory networks (TRNs) beyond the context of model organisms have been studied extensively. However, little is still known about the structure and functionality of TRNs that control metabolic physiological processes. In this study, we present a newly version of the TRN of E.coli controlling metabolism based on functional annotations from GeneProtEC and Gene Ontology (GO). We also present an exhaustive topological analysis of the metabolic transcriptional regulatory network (MTRN), focusing on the main statistical characterization describing the topological structure and the comparison with TRN. From the results in this paper we infer that TRN and MTRN have very similar characteristic distribution.