HEATING EFFECTS OF THE MAGNETIC-NANOPARTICLE ENHANCED HYPERTHERMIA TARGETING TUMORS UNDERNEATH THE RIBS

摘要

Aiming at providing a detailed disclosure on the thermal effects of EM (electromagnetic) hyperthermia on the liver tumor underneath the ribs, this paper has numerically provided comprehensive interpretations on the heating effects of magnetic nano-particles induced hyperthermia for target tumor treatment. The results revealed the following factors: (1) The existing of bone structure, i.e. ribs has an inevitable effect on the distribution of EM field; specifically, due to its lower dielectric property, the bone structure seemingly acts as a barrier to attenuate the access of EM energy into the tissue, especially the tumor in the deep body. (2) Using higher dosage or bigger size magnetic nano-particles have greatly enhanced the temperature elevation of targeted tumor tissue and thereby obtain good performance of hyperthermia. (3) Further parametric studies indicated that a worse heating effect would be obtained when utilizing external EM field with a higher frequency of 10MHz; while higher strength of EM field would evidently enhance the heating effects of such EM hyperthermia. The present study would promote the understandings of thermal effects on the specific organs in EM hyperthermia, and the findings are expected to provide valuable guidance for planning an accurate dosage in clinical liver tumor thermal ablation.