Antimicrobial Study of Symmetrical Gemini Cationic Surfactant Based on N-hexadecyldimethylamine

摘要

Gemini surfactants generally exhibit superior properties to those of their single-chain analogues with a similar chain length and head group, especially for gemini cationic surfactants. Gemini cationic surfactants have recently attracted considerable attention due to the increasing microbial resistance to common quaternary ammonium compounds. A novel symmetrical gemini cationic surfactant based on n-hexadecyldimethylamine was synthesized through epichlorohydrin and n-hexadecyldimethylamine as rude materials. The chemical structure of the product was confirmed using ~1H-NMR and FT-IR. The minimum inhibitory concentration of the surfactant to escherichia coli rises to 100 ppm, and a higher concentration surely contributes to increase its effect, but staphylococcus aureus is immune to this surfactant.