Effect of Roxithromycin on the morphology of tissues in the liver of Cipangopaludina chinensis

摘要

Cipangopaludina chinensis was exposed to Roxithromycin, and the first, the fifth and the tenth days of the C. chinensis were chosen, then the liver of the C. chinensis were made into slices. The results showed that the live treated by Roxithromycin had shown certain changes in the structure. The liver cells were disorganized, and the number of fat bubbles increased. What's more, some nucleus deviated from the original position, and the number of ovarian follicles increased, too. This paper explored the effect of Roxithromycin in water on the morphology of tissues in C. chinensis in order to provide a reference about the environment of the growth of benthonic animals, and provide basis for the controlling and management of the water pollution as well as the bioremediations of water environment. Roxithromycin (RM) is Macrolide antibiotic, Chemical name is (9E)-[O-[(2-methoxyethoxy) methyl]oxime] erythromycin, molecular formula is C_(41)H_(76)N_2O_(15), molecular weight is 837. At present, roxithromycin is one of the most commonly used antibiotics of clinical. Antibiotics can make bacteria become resistant and make the resistance gene to produce selective evolution in organisms and environment. In order to know the contamination in sediments, the benthic animal Cipangopaludina chinensis were proceed with roxithromycin, then the liver histological changes were observed after the treatment of roxithromycin through the liver tissue slices.