In vitro Evaluation of Anticancer Effect and Neurotoxicity of Styrylpyrone Derivative (SPD)

摘要

The increasing number of death due to cancer emphasizes the need of novel anticancer agents. Styrylpyrone derivative (SPD) was previously found to have potential anticancer action towards many types of cancer. Some of the SPD-anticancer mechanisms were elucidated as induction of cancer cell apoptosis. However, more understanding on cancer cell type specific action of SPD-anticancer effects needs to be evaluated. HCT-116 cell line, a type of human colon carcinoma, was used to study SPD-anticancer effect. It was found that SPD concentration as low as 0.25 μM was able to inhibit 80% growth of cancer cells. IC_(50) value of SPD for HCT-116 was found to be 0.038 μM. Neurotoxicity test, carried out to determine the adverse effect of SPD towards nerve cells, gives CC_(50) value as 4.88 μM, thus concluded it to be a neurotoxic compound.