Evaluation of F127/chitosan hydrogel as a scaffold for bone repair

摘要

An in situ gelled scaffold for bone tissu engineering to restore the function of bone tissus is developed. The gel is comprised of Pluronic F127 and chitosan. The gelation temperature (T_(gel)), and viscoelastic properties and mucoadhesive force of the systems were investigated by means of rheological analyses. At specific concentrations, the hydrogel exhibited a Tgel close to the body temperature du to the addition of chitosan. Mucoadhesion experiments showed a rheological synergism between F127/chitosan gels and mucin dispersion, and a change in the flow behavior. In vitro release results indicated that the optimized gel was able to prolong and control acyclovir release for more than 20 min. Based on cell proliferation assay, the gel exhibited biocompatibility for osteoblasts.