Intracoronary infusion of autologous CD133~+ cells in myocardial infarction and tracing by Tc-99m MIBI scintigraphy of the heart areas involved in cell homing

摘要

Autologous transplantation of bone marrow derived CD133+ was undertaken with the high degree of success for a cohort of patients with heart disease. Single Intracoronary infusion of autologous CD133/CD34~+ BMMNCs are effective and reduce infarct size in patients as analyzed by Tc-99m MIBI myocardial scintigraphy. Majority of patients were treated via left coronary artery. 9 months after cell therapy, 5 out of 8 patients showed a net positive response to therapy in different regions of the heart. Uptake of Tc99 isotope and revitalization of the heart area in Inferoseptal region is more pronounced (p=0.016) as compared to apex and anterosptal regions after intracoronary injection of the stem cells. The cell therapy proposed here is safe and should be practiced, as we found, in conjunction with scintigraphic observation of areas of heart which respond optimally to the infusion of autologous CD133~+/CD34~+BMMNCs.