Formulation and Evaluation Of Avocado Oil Nanoemulsion Hydrogels Using Sucrose Ester Laureate

摘要

Nanoemulsion is a new class of emulsion with uniform and extremely small droplet sizes, typically in the range of 20-200 nm. Avocado oil was proven to be used as anti-aging and moisturizing agent. This study aimed to characterize nanoemulsion hydrogels prepared using avocado oil and sucrose ester laureate as surfactant. The nanoemulsion hydrogels were prepared by nanophase emulsification technique. These formulations were examined using zetasizer to determine the mean diameter of dispersed oil droplets, polydispersibility index (PDI) and zeta potential. The viscosity of the prepared nanoemulsion hydrogel was also studied. The results revealed that nanoemulsions prepared with 50% w/w oil, 30% w/w glycerol and 20% w/w surfactant showed droplets size below 200 nm with good polydispersibility index and zeta potential < -30 mV. The optimum formulation of nanoemulsion was prepared in the form of nanoemulsion hydrogel using carbopols 934 and 940. The results of the rheology for the nanoemulsion hydrogel showed that the storage modulus (G') which describes the elasticity of the component were greater than the loss modulus (G") values that reveals the viscosity of the component.