Experimental Studies on Toxic Interaction of Oxytetracycline and Cadmium

摘要

These experimental studies were carried out on 450 Ross chicks divided into 6 groups.Some of these groups administered a therapeutic dose of oxytetracycline(OTC)plus cadmium(0.1 ppm cadmium chloride in drinking water),other groups were given over concentration of OTC (6g/l of drinking water),double the therapeutic dose plus the same dose of cadmium chloride.It had been reported that administration of OTC,OTC plus cadmium had a serious effect on both the muscular tissue and the parynchymatous organs including hepatocellular degeneration,focal lymphoid cell reaction and fibroblastic reaction in the portal area of liver,nephrosis of kidney with degeneration of some renal tubules and depletion of lymphoid cells of white pulp of spleen.It was also associated with cellular immune suppression.So new laws regulating administration of antibiotic should be enforced.